Lymphoid cells show an adapted NK cell population in latent tuberculosis cases
In a study of NK cell repertoire and tuberculosis (TB), Garand and coworkers found a diversified population of NK cells in latently infected individuals versus active TB cases. NK cells from latently infected individuals exhibited a higher frequency of memory-type surface markers. The results indicate a primed NK cell population resulting from previous TB exposure, thus, bridging innate and adaptive immunity.
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Garand, M., Goodier, M., Owalabi, O., Donkor, S., Kampmann, B., Sutherland, J.S. Functional and Phenotypic changes of natural Killer cells in Whole Blood during Mycobacterium tuberculosis infection and Disease. Front Immunol 9, doi.org/10.3389/fimmu.2018.00257 (2018).
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